Development of Duloxetine Hydrochloride Loaded Mesoporous Silica Nanoparticles: Characterizations and In Vitro Evaluation
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چکیده
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Preparation and In-vitro Evaluation of Rifampin-loaded Mesoporous Silica Nanoaggregates by an Experimental Design
The goal of this research is preparation, optimization and in-vitro evaluation of rifampin-loaded silica nanaoparticles in order to use in pulmonary drug delivery. Nanoparticles are exhaled because of thier small size, Preparation of nanoaggregates in micron-sized scale and re-disrpersion of them after the deposition in the lung is one approach in order to overcome this problem, which we used i...
متن کاملPreparation and In-vitro Evaluation of Rifampin-loaded Mesoporous Silica Nanoaggregates by an Experimental Design
The goal of this research is preparation, optimization and in-vitro evaluation of rifampin-loaded silica nanaoparticles in order to use in pulmonary drug delivery. Nanoparticles are exhaled because of thier small size, Preparation of nanoaggregates in micron-sized scale and re-disrpersion of them after the deposition in the lung is one approach in order to overcome this problem, which we used i...
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Cisplatin continues to be a first line chemotherapy agent alone or in combination with other cytotoxic agents orradiotherapy. Dose-limiting side effects, intrinsic and acquired resistance are the main reasons for inventing and developing new ways of delivering cisplatin. Biocompatible hollow porous materials offer high void volume, shell porosity, low density and controllable size which make th...
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Mesoporous silica nanoparticles (MSNs) have been synthesized and loaded with both aluminum chloride phthalocyanine (AlClPc) and cisplatin as combinatorial therapeutics for treating cancer. The structural and photophysical properties of the MSN materials were characterized by different spectroscopic and microscopic techniques. Intracellular uptake and cytotoxicity were evaluated in human cervica...
متن کاملpreparation and in-vitro evaluation of rifampin-loaded mesoporous silica nanoaggregates by an experimental design
the goal of this research is preparation, optimization and in-vitro evaluation of rifampin-loaded silica nanaoparticles in order to use in pulmonary drug delivery. nanoparticles are exhaled because of thier small size, preparation of nanoaggregates in micron-sized scale and re-disrpersion of them after the deposition in the lung is one approach in order to overcome this problem, which we used i...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2015
ISSN: 1530-9932
DOI: 10.1208/s12249-014-0273-x